February 19, 2020
CONTRAST-ENHANCED ULTRASOUND FOR ASSESSMENT OF LOCAL HEMODYNAMIC CHANGES FOLLOWING A RODENT CONTUSION SPINAL CORD INJURY
CEUS imaging showed that traumatic SCI results in an area with significant loss of perfusion, which increased during the first hour after injury, structural alterations of the spinal cord vasculature, and significant slowing of arterial blood flow velocities around the injury epicenter.
January 21, 2020
TRANSCUTANEOUS CONTRAST-ENHANCED ULTRASOUND IMAGING OF THE POST-TRAUMATIC SPINAL CORD
"This study aims to test whether the blood flow within the contused spinal cord can be assessed in a rodent model via the acoustic window of the laminectomy utilizing transcutaneous ultrasound. We report that transcutaneous ultrasound allows for measurements and longitudinal monitoring of local hemodynamic changes in a rodent SCI model."
Journal of Neurosurgery
CONTRAST-ENHANCED ULTRASOUND TO VISUALIZE HEMODYNAMIC CHANGES AFTER RODENT SPINAL CORD INJURY
Zin Z. Khaing, Lindsay N. Cates, Dane M. DeWees, Alexander Hannah, Pierre Mourad, Matthew Bruce, and Christoph P. Hofstetter
"In our current report, we introduce ultrafast CEUS Doppler for monitoring of spinal vascular structure and function in real time. Development and clinical implementation of this type of imaging could have a significant impact on the care of patients with tSCI."
Journal of Neurotrauma
February 1, 2017
TEMPORAL AND SPATIAL EVOLUTION OF RAISED INTRASPINAL PRESSURE AFTER TRAUMATIC SPINAL CORD INJURY
Zin Z. Khaing, Lindsay N. Cates, Amanda E. Fischedick, Abbi M. McClintic, Pierre D. Mourad, and Christoph P. Hofstetter
"Here, we report on the temporal and spatial patterns of elevated ISP following a moderate rodent contusion SCI. Our findings suggest that a rat contusion SCI model in combination with novel micro-catheters allows for direct measurement of ISP after SCI. Similarly to traumatic brain injury, raised tissue pressure is likely to have detrimental effects on spontaneous recovery following SCI."
Journal of Neurotrauma
October 29, 2020
THE EFFECT OF DUROTOMY VERSUS MYELOTOMY ON TISSUE SPARING AND FUNCTIONAL OUTCOME AFTER SPINAL CORD INJURY
Surgical decompression of either the dural (durotomy) or the dural and pial (myelotomy) lining of the spinal cord has been proposed. We compare the histological and functional effects of durotomy alone and durotomy + myelotomy in a rodent model of acute thoracic tSCI. Our data suggest that durotomy + myelotomy following acute tSCI facilitates tissue sparing and recovery of locomotor function.
Individual Work, Prior Work, Case Studies, Collaborations, etc.
IMAGING METHODS FOR ULTRASOUND CONTRAST AGENTS
MA Averkiou, MF Bruce, JE Powers, PS Sheeran, PN Burns
TRANSCUTANEOUS ELECTRICAL SPINAL STIMULATION PROMOTES LONG-TERM RECOVERY OF UPPER EXTREMITY FUNCTION IN CHRONIC TETRAPLEGIA
May 8, 2018
F Inanici, S Samejima, P Gad, VR Edgerton, CP Hofstetter, CT Moritz
BIOMIMETIC HYDROGELS DIRECT SPINAL PROGENITOR CELL DIFFERENTIATION AND PROMOTE FUNCTIONAL RECOVERY AFTER SPINAL CORD INJURY
Feb 14, 2018
SA Geissler, AL Sabin, RR Besser, OM Gooden, BD Shirk, QM Nguyen, ZZ Khaing, CE Schmidt